Overwhelming evidence substantiates that RNA m 6A modification represents a significant role in the immune system. Since then, a mounting number of studies have substantiated m 6A modification in various cell types, unveiling the mystery of m 6A in a wide range of physiological and pathological processes, such as stem cell differentiation ( 7), the maintenance of pluripotency in embryonic development ( 8), X chromosome inactivation ( 9), virus replication ( 10), and the generation, development, invasion, metastasis, and drug resistance of cancer cells ( 11). Until 2012, m 6A-specific methylated RNA immunoprecipitation with next-generation sequencing (MeRIP-seq) was established and an extensive study of m 6A modification was conducted by transcriptome analysis ( 5, 6). However, due to the lack of m 6A-mapping methods, research on m 6A has been in the initial stage for a long time. The first report about m 6A was published in 1974 ( 4). N6-methyladenosine (m 6A), a modification occurring at the 6th position of adenine (A) bases, is the most prevalent internal RNA modification ( 3). Among them, RNA methylation is one of the predominant forms, accounting for more than 60% of RNA modifications ( 2). To date, more than 100 RNA modifications have been identified in eukaryotes ( 2). RNA stability largely depends on its modification, one of the most important post-transcriptional regulations ( 1). RNA is widely acknowledged to play an extremely important role in living organisms.
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